Qing Robert Miao, PhD
As a vascular biologist and cancer biologist, I have made significant research contributions to elucidate the roles of the Nogo-B receptor in regulating vascular integrity, metabolism, and tumorigenesis. I also serve as an observer for NYU Long Island School of Medicine Tenured/Tenure Track Faculty Senators Council and for the institutional animal care and use committee.
After earning my PhD at the Medical University of South Carolina, I completed my postdoctoral training at Yale University School of Medicine. Throughout 2006 and 2018, I developed my academic career, progressing from an associate research scientist at Yale University School of Medicine to become a full professor at the Medical College of Wisconsin. I was selected to be a Fellow of the American Heart Association (AHA) in 2017 and received the Mid-career Investigator Award from the AHA Council on Peripheral Vascular Disease.
My research interests focus on elucidating the biological functions of the Nogo-B receptor (NgBR)and its roles in the pathogenesis of human diseases. The NgBR is a cell surface receptor that I identified during my postdoctoral training in Dr. William Sessa’s laboratory at Yale. Our work demonstrated that NgBR is a vital gene required for development and that loss of NgBR causes early embryonic lethality.
We have elucidated the unique properties of NgBR that bind to prenylated Ras and that regulate Ras plasma membrane translocation, which is a crucial cell process required for many receptor tyrosine kinase-mediated pathways. This discovery reveals why NgBR is an essential gene for development and opens a research avenue for developing a new therapeutic approach that targets the concurrent receptor tyrosine kinase-mediated tumorigenic pathways.
We successfully connect our bench work with human diseases and strengthen the translational aspect of our research through collaboration with clinical colleagues. Based on the determination of physiological defects happened in NgBR tissue-specific knockout mice, we successfully established several unique animal models for elucidating the novel underlying mechanisms of human diseases, such as cerebrovascular malformations and nonalcoholic fatty liver diseases. My career establishment has been evidenced by the continuous success of NIH and AHA funding and increasing peer-review publications.
Currently, we extend our research interests to investigate the contribution of metabolites to histone protein acetylation and epigenetic alterations occurring in metabolic diseases and cancer. We hope our findings will lead to developing epigenetic interventions to restore a healthy epigenome.
Education and Training
- Postdoctoral Fellow, Yale University School of Medicine, 2006
- PhD, Medical University of South Carolina, 2002
NYU Langone Hospital—Long Island
Diabetes and Obesity Research Center
101 Mineola Boulevard, Suite 4-038
Mineola, NY 11501