Mahmood Hussain, PhD
As an internationally renowned expert in lipid biology and cardiovascular disease, I have made significant research contributions to the field of lipid and lipoprotein metabolism. I also serve as a teacher, researcher, and administrator at NYU Long Island School of Medicine, as well as at other biochemistry and physiology organizations.
After earning my PhD at Oklahoma State University and my medical degree from the University of Copenhagen, I completed my postdoctoral work at Boston University School of Medicine and at the Gladstone Institutes of the University of California, San Francisco.
Throughout the 1990s and 2000s, I held various faculty appointments at the Medical College of Pennsylvania and SUNY Downstate Medical Center and was selected to be Fellow of the American Heart Association (AHA). I’ve since founded and served as president of Chylos Inc. and Chylos Therapeutics Inc., with the goal of marketing microRNAs for the treatment of hyperlipidemia and atherosclerosis.
My research interests include understanding the metabolism of chylomicrons, which are lipoproteins synthesized by the intestine to transport dietary fat and fat-soluble vitamins. My findings show that bone marrow plays a role in the catabolism of chylomicrons, and I have established cell culture systems to study chylomicron assembly and secretion.
Using these systems, I have investigated the transport of phospholipids, triglycerides, cholesterol, and vitamin A across the intestinal epithelial cells. I have also studied the role of protein–protein interactions between apolipoprotein B and microsomal triglyceride transfer protein (MTP) in lipoprotein assembly.
My current research focuses on how MTP is regulated by circadian rhythms, endoplasmic reticulum stress, and microRNA; and the discovery of several novel microRNAs that regulate plasma low-density lipoprotein cholesterol and high-density lipoprotein cholesterol.
In recognition of my research, I have received several awards, including the Council on Arteriosclerosis, Thrombosis, and Vascular Biology’s Irvine H. Page Award, the AHA’s Leonard N. Horowitz Research Award, the AHA’s Established Investigator Award, the International Journal of Molecular Medicine’s Outstanding Achievement award, and The Research Foundation for the State University of New York’s Promising Inventor Award.
I served as president of the New York Lipid and Vascular Biology Research Club from 2001 to 2002 and presided over the Downstate Lipid and Vascular Biology Club from 2000 to 2016. I also serve on various grant review committees of the AHA, Veterans Administration, and the National Institutes of Health (NIH).
Currently, I am the chair of the Integrative Nutrition and Metabolic Processes Study Section at the NIH Center for Scientific Review. I’ve received continuous grant support from the NIH and AHA for my research.
Education and Training
- MD, University of Copenhagen, 1986
- PhD, Oklahoma State University, 1984