Louis Ragolia, PhD
My research is primarily focused on cardiovascular complications associated with obesity and type 2 diabetes. Over the past 25 years, I have conducted and supervised research focused on several aspects of insulin signaling at the molecular level. Using a combination of molecular and cellular techniques, we have revealed novel signaling pathway defects present in diabetes that contribute to insulin resistance, impaired glucose homeostasis, and atherosclerosis.
We are currently exploring the mechanisms responsible for the reversal of diabetes after bariatric surgery. Using both clinical studies and mouse models, we are analyzing the signaling mechanisms responsible for the beneficial metabolic and cardiovascular improvements observed in response to Roux-en-Y bypass, even prior to significant weight loss. We hope one day to “bypass the bypass” and harness the beneficial effects of the procedure without surgery.
My other research interests include vitamin D and prostaglandin metabolism. One of the most exciting aspects of working in the field of prostaglandin metabolism has been their ubiquitous nature and overlap into several seemingly unrelated areas of research. An example of this is the effects of prostaglandins on the cell cycle and the role of prostaglandins in lung cancer.
We have also applied our knowledge of prostaglandins to the field of preterm birth and have recently received a U.S. patent for a non-invasive biomarker to identify women at risk of preterm birth. In fact, we are in the process of developing a clinical test to predict preterm birth with a biotech company that specializes in diagnostic tests for women’s health.
We have been most fortunate over the years to receive generous funding from the American Diabetes Association, the American Heart Association, the National Institutes of Health, March of Dimes, Amgen Pharmaceuticals, Reata Pharmaceuticals, The George Link Foundation, and The Theresa Santmann Foundation.
Education and Training
- PhD, Queens College, City University of New York, Biochemistry and Molecular Biology, 1994
- BS, Stony Brook University, Biochemistry, 1985
NYU Winthrop Hospital
101 Mineola Boulevard, Suite 4-003
Mineola, New York 11501